From Chapter 1:
"'It requires no effort of the fancy to picture these three men [Shakespeare, Bacon and Raleigh] as lounging in a window of Durham House, puffing the new Indian weed from silver bowls, discussing the highest themes in poetry and science, while gazing on the flower-beds and the river, the darting barges of dame and cavalier, and the distant pavilions of Paris garden and the Globe.'" This is a pure "effort of the fancy" so far as Bacon and Shakespeare are concerned. Shakespeare's absolute silence about tobacco forbids us to assume that he smoked; but of Raleigh the picture may be true enough. The house had, as Aubrey tells us, "a little turret that looked into and over the Thames, and had the prospect which is as pleasant perhaps as any in the world"; and it would be strange indeed if the owner of the noble house did not often smoke a contemplative pipe in the window of that pleasant turret.

From Chapter 6:
But so early as 1655 there is a sign of change of custom—a change, that is, in the direction of restricting and limiting the hitherto unbounded freedom granted to the use of tobacco. The London Society of Apothecaries on August 15, 1655, held a meeting for the election of a Master and an Upper Warden; and from the minutes of this meeting we learn that by general consent it was forbidden henceforward to smoke in the Court Room while dining or sitting, under penalty of half a crown.