From Chapter 4:
The variations in price of both Spanish and Virginia tobacco were largely due to the frequent changes in the amount of the duty thereon. In 1604 King James I, newly come to the throne, and full of iconoclastic fervour against the weed, raised the duty to 6s. 8d. per lb. in addition to the original duty of 2d. On March 29, 1615, there was a grant to a licensed importer "of the late imposition of 2s. per lb. on tobacco"—which shows that there must have been considerable fluctuation between 1604 and 1615—while in September 1621 the duty stood at 9d. Through James's reign much dissatisfaction was expressed about the importation of Spanish tobacco, and the outcome of this may probably be seen in the proclamations issued by the King in his last two years forbidding "the importation, buying, or selling tobacco which was not of the proper growth of the colonies of Virginia and the Somers Islands." These proclamations were several times confirmed by Charles I, the latest being on January 8, 1631; but they do not seem to have had much effect.

From Chapter 5:
The belief in the prophylactic power of tobacco was, however, very generally held. When Mr. Samuel Pepys on June 7, 1665, for the first time saw several houses marked with the ominous red cross, and the words "Lord, have mercy upon us" chalked upon the doors, he felt so ill at ease that he was obliged to buy some roll tobacco to smell and chew. There is nothing to show that Pepys even smoked, which considering his proficiency in the arts of good-fellowship, is perhaps a little surprising. Defoe, in his fictitious but graphic "Journal of the Plague Year in London," says that the sexton of one of the London parishes, who personally handled a large number of the victims, never had the distemper at all, but lived about twenty years after it, and was sexton of the parish to the time of his death. This man, according to Defoe, "never used any preservative against the infection other than holding garlic and rue in his mouth, and smoking tobacco."