From Chapter 3:
Another tract which may be classed with Venner's "Treatise" was the "Nepenthes or the Vertues of tobacco," by Dr. William Barclay, which was published at Edinburgh in 1614. This is sometimes referred to and quoted, as by Fairholt, as if it were a whole-hearted defence of tobacco-taking. But Barclay enlarges mainly on the medicinal virtues of the herb. "If Tabacco," he says, "were used physically and with discretion there were no medicament in the worlde comparable to it"; and again: "In Tabacco there is nothing which is not medicine, the root, the stalke, the leaves, the seeds, the smoake, the ashes." The doctor gives sundry directions for administering tobacco—"to be used in infusion, in decoction, in substance, in smoke, in salt." But Barclay clearly does not sympathize with its indiscriminate use for pleasure. "As concerning the smoke," he says, "it may be taken more frequently, and for the said effects, but always fasting, and with emptie stomack, not as the English abusers do, which make a smoke-boxe of their skull, more fit to be carried under his arme that selleth at Paris dunoir a noircir to blacke mens shooes then to carie the braine of him that can not walke, can not ryde except the Tabacco Pype be in his mouth." He goes on to say that he was once in company with an English merchant in Normandy—"betweene Rowen and New-haven"—who was a merry fellow, but was constantly wanting a coal to kindle his tobacco. "The Frenchman wondered and I laughed at his intemperancie."

From Chapter 8:
Says the Pipe to the Snuff-box, I can't understand
What the ladies and gentlemen see in your face,
That you are in fashion all over the land,
And I am so much fallen into disgrace.
- William Cowper.
(From a letter to the Rev. John Newton, May 28, 1782.)

"smoking has gone out," said Johnson in talk at St. Andrews, one day in 1773. "To be sure," he continued, "it is a shocking thing, blowing smoke out of our mouths into other people's mouths, eyes and noses, and having the same thing done to us; yet I cannot account why a thing which requires so little exertion, and yet preserves the mind from total vacuity, should have gone out." Johnson did not trouble himself to think of how much the vagaries of fashion account for stranger vicissitudes in manners and customs than the rise and fall of the smoking-habit; nor did he probably foresee how slowly but surely the taste for smoking, even in the circles most influenced by fashion, would revive. Boswell tells us that although the sage himself never smoked, yet he had a high opinion of the practice as a sedative influence; and Hawkins heard him say on one occasion that insanity had grown more frequent since smoking had gone out of fashion, which shows that even Johnson could fall a victim to the post hoc propter hoc fallacy.